Dr Andrea Harrington

• Biography/ Background

  Dr. Harrington is a laboratory based scientist whose research explores the neural circuits in the spinal cord and brain processing pain sensations arising from visceral organs such as the gastrointestinal tract and bladder. A post-doctoral research fellow with the University of Adelaide she is a member of the Visceral Pain Research Group located at the South Australian Health and Medical Research Institute. Dr. Harrington uses multiple approaches in molecular biology and integrative physiology to characterise the central pathways signalling visceral pain and how they change in conditions of chronic visceral pain.

   

• Research Funding

   Australian Research Council (ARC) Discovery Early Career Research Award (2013-2017) 

   DE130100223 "Characterisation of visceral afferent spinal pathways" 

   

  ARC Discovery Project 2018-2020
  Harrington, Brierley, Mazzone and Rychkov
  DP180101395 "Central pathways regulating visceral pain."

   

• Publications

           a) Book chapters:

  1. Blackshaw L.A, Brierley S.M, Harrington A.M, and Hughes PA. ‘TRP channels in visceral pain’. The Open Pain Journal. 6, 2013 (Suppl 1: M4) 23-30.

   

  2. Hughes P.A, Brierley S.M, Castro J, Harrington AM and Blackshaw LA. “Experimental Models of Colitis”. Arpad Szallasi and Tamás Bíró (eds.), TRP Channels in Drug Discovery: Volume II, Methods in Pharmacology and Toxicology. 2012. DOI 10.1007/978-1-62703-095-3_23

   

  3. Brierley S.M, Hughes P.A and Harrington A.M, Blackshaw L.A. “Innervation of the Gastrointestinal Tract by Spinal and Vagal Afferent Nerves”. In: LR Johnson (Editor-In-Chief) Physiology of the Gastrointestinal Tract. 5th edition. Elsevier Academic press. 2012. pp. 703-732.

   

  b) Refereed journal articles:

  4. Inserra M, Israel M, Caldwell A, Castro J, Deuis J, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis R, Brierley S.M, Vetter I. Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports. 2017 7: 42810. doi: 10.1038/srep42810 Impact Factor (IF): 5.22 citations: 2 The research undertaken as part of DE130100223 2013-2017 contributed towards this paper.

   

  5. Campaniello MA, Mavrangelos C, Eade S, Harrington AM, L. Ashley Blackshaw, Brierley SM, Smid SD, Hughes PA. Acute colitis chronically alters immune infiltration mechanisms and sensory neuro-immune interactions. Brain Behav. Immun. 2017 60:319-332 doi: 10.1016/j.bbi.2016.11.015. IF: 5.889 citations: 0

   

  6. Castro J*, Harrington AM*, Garcia-Caraballo S, Maddern J, Grundy L, Zhang J, Page G, Miller PE, Craik DJ, Adams DJ, Brierley SM. α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut. 2016. pii: gutjnl-2015-310971. doi: 10.1136/gutjnl-2015-310971. *Equal first authors IF: 14.66 citations: 4 The research undertaken as part of DE130100223 2013-2017 contributed towards this paper.

   

  7. Campaniello MA, Harrington AM, Martin CM, Ashley Blackshaw L, Brierley SM, Hughes PA. Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity. Neurogastroenterol Motil. 2016 28(1):54-63. doi: 10.1111/nmo.12696. IF: 3.5 citations: 37

   

  8. de Araujo AD, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM, Alewood PF. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nat Commun. 2014. 5:3165. doi: 10.1038/ncomms4165. IF: 10.15 citations: 4

   

  9. Hughes PA, Castro J, Harrington AM, Isaacs N, Moretta M, Hicks GA, Urso DM, Brierley SM. Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut. 2014 63(7):1199-200. doi: 10.1136/gutjnl-2013-306240. IF:10.73 citations: 6

   

  10. Castro J, Harrington AM, Hughes PA, Martin CM, Ge P, Shea CM, Jin H, Jacobson S, Hannig G, Mann E, Cohen MB, MacDougall JE, Lavins BJ, Kurtz CB, Silos-Santiago I, Johnston JM, Currie MG, Blackshaw LA, Brierley SM. Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate. Gastroenterology. 2013 145(6):1334-46.e1-11. doi: 10.1053/j.gastro.2013.08.017. IF: 12.81 citations: 24

   

  11. Harrington AM, Brierley SM, Isaacs N, Young R and Blackshaw LA. Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility. 2013 25(10):e660-8. doi: 10.1111/nmo.12180. IF: 2.94 citations: 3

   

  12. Kentish SJ, O'Donnell TA, Iaacs NJ, Young RL, Li H, Harrington AM, Brierley SM, Wittert GA, Blackshaw LA, Page AJ. Gastric vagal afferent modulation by leptin is influenced by food intake status. J Physiol. 2013 591:1921-34. IF: 4.38 citations: 10

   

  13. Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Isaacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann G, Blackshaw LA, Brierley SM. Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut. 2012 Jul 27 (epub). IF: 10.73 citations: 22

   

  14. Harrington AM, Brierley SM, Isaacs N, Hughes PA, Castro J, Blackshaw LA. Sprouting of colonic afferent central terminals and increased spinal MAP kinase expression in a mouse model of chronic visceral hypersensitivity. J Comp Neurol. 2012. 520(10):2241-55 doi: 10.1002/cne.23042  IF: 3.66. citations: 6 (Faculty 1000 nominated publication).

   

  15. Blackshaw LA, Brierley SM, Hughes PA, Harrington AM. The hot mustard receptor's role in gut motor function. Gastroenterology. 2011 141(2): 565- 575 IF: 12.03 citations: 1

   

  16. Brierley SM, Castro J, Harrington AM, Hughes PA, Page AJ, Rychkov GY, Blackshaw LA. TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J Physiol. 2011 589:3575-93 IF: 4.38 citations: 23

   

  17. Harrington AM, Hughes PA, Martin CM, Yang J, Castro J, Isaacs NJ, Blackshaw LA and Brierley SM. A novel role for TRPM8 in visceral afferent function. Pain. 2011 152(7):1459-1468 IF: 6.30 citations: 24

   

  19. Brierley SM, Hughes PA, Harrington AM, Rychkov GY and Blackshaw LA. Identifying the Ion Channels Responsible for Signalling Gastrointestinal Based Pain. Pharmaceuticals. 2010 3(9): 2768- 2798

   

  22. Brierley SM, Hughes PA, Page AJ, Kwan KY, Martin CM, O'Donnell TA, Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY, Blackshaw LA. The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology 2009 137(6): 2084- 2095 IF: 12.03 citations: 60

   

  c) Fully refereed conference proceedings:

  1.   Castro J, Deiteren A, Harrington A, Maddern J, Moore J, Garcia-Caraballo S, O'Donnell T, Grundy L, Hannig G,

  Kurtz C, Silos-Santiago A, and Brierley S. Chronic Oral Administration of Linaclotide Inhibits Nociceptive Signalling

  in Response to Noxious Colorectal Distension in a Model of Chronic Visceral Hypersensitivity.  Digestive Disease

  Week 2017 Gastroenterology 152.5 (2017): S204.

   

  2.   Garcia-Caraballo S., Harrington A.M., Castro J., Hannig G., Kurtz C., Silos-Santiago A., Chang L. and Brierley

  S.M. Guanylate cyclase-C expression is down-regulated in colonic biopsies from female irritable bowel syndrome

  patients with constipation. Digestive Disease Week 2016. Gastroenterology 150.4 (2016): S81-S82

   

  3.   Castro, J., Harrington, A.M., Lieu, T., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., Poole, D.P.,

  Bunnett, N.W. and Brierley, S.M. A Visceral Representation of Itch: Identification ‘Itch-Specific'Pruritogenic

  Mechanisms Within Colonic Sensory Pathways. Digestive Disease Week 2015. Gastroenterology 148.4 (2015): S733

  S733.

   

  4.   Harrington, A.M., Castro, J., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., Rychkov, G.Y., Kurtz,

  C.B., Silos-Santiago, A. and Brierley, S.M. GC-C Agonists As Regulators of Visceral Sensation: Modulation of

  Mucosal Sensitivity via the Epithelial GC-C/cGMP Pathway.  Digestive Disease Week 2015. Gastroenterology 148.4

  (2015): S-732.

   

  5.   Castro, J., Harrington, A.M., Garcia-Caraballo, S., Maddern, J., O'Donnell, T., Grundy, L., Kurtz, C.B., Silos-

  Santiago, A. and Brierley, S.M. Chronic Activation of the GC-C/cGMP Pathway by Linaclotide Inhibits Ascending

  Nociceptive Pathways and Restores Aberrant Spinal Cord Signalling. Digestive Disease Week 2015 Gastroenterology

  148.4 (2015): S-194.

   

  6.   Harrington, A.M., Castro, J., Garcia-Caraballo, S., Maddern, J., Craik, D., Adams, D.J. and Brierley, S.M. α-

  Conotoxin Vc1. 1 Targets GABAB Receptors Modulating CaV2. 2 and CaV2. 3 Calcium Channels in Sensory

  Pathways Mediating Chronic Visceral Pain.  Digestive Disease Week 2014 Gastroenterology 146.5 (2014): S-156.

   

  7.   Harrington AM, Castro J, Young RL, Kurtz C, Silos-Santiago A, Nguyen N, Andrews  JM and Brierley SM.

  Alterations in the guanylate cyclase-C/cGMP pathway in patients with Irritable Bowel Syndrome with constipation.

  Digestive Disease Week 2013 Gastroenterology 144.5 (2013): S-59.

   

  8.   Castro J, Harrington AM, Hughes PA, Martin CM, Silos-Santiago A, Kurtz C, Blackshaw LA and Brierley M.

  Mechanism of action for linaclotide induced abdominal pain relief. Digestive Disease Week 2013 Gastroenterology

  144.5 (2013): S-134.

   

  9.   McGuire C, Harrington AM, Hubball A, McPhail H, Peiris M, Bulmer DC, Knowles CH, and Blackshaw LA.

  Anatomical Sensory Nerve Markers in the Human Gut. Digestive Disease Week 2013 Gastroenterology 144.5 (2013):

  S-56.

   

  10.        Harrington AM, Castro J, Young RL, Kurtz C, Silos-Santiago A, Nguyen N, Andrews JM, and Brierley SM.

  The guanylatecyclase-c/cgmp pathway is altered in patients with irritable bowel syndrome with constipation. American Neurogastroenterology and Motility meeting 2013. Neurogastroenterology & Motility 25 (2013): 1.

   

  11.            Harrington AM, Castro J and Brierley SM. Peripheral modulation of Trpa1 alters dorsal horn neuron activation

  to colorectal distension. American Neurogastroenterology and Motility meeting 2013. Neurogastroenterology &

  Motility. 25 (2013):17.

   

  12.        Harrington AM, Brierley SM, Castro J, Isaacs NJ and Blackshaw LA. Characterization of dorsal horn neurons

  activated by noxious colorectal distension in health and chronic visceral hypersensitivity. Digestive Disease Week

  2012. Gastroenterology 142.5 (2012): S-699.

   

  13.        Castro J, Harrington AM, Page AJ and Brierley SM. Downstream signalling pathways of nitric oxide induced

  modulation of colonic afferent mechanosensitivity. Digestive Disease Week 2012. Gastroenterology 142.5 (2012): S697.

• Professional Associations

  Nerve Gut Research Laboratory

  Disc. of Medicine, University of Adelaide

Entry last updated: Thursday, 21 Dec 2017