Professor Gerald Atkins

• Biography/ Background

  Prof. Gerald Atkins graduated from the University of Adelaide with a B.Sc.(Hons), PhD in 1998. Since then he has pursued a strong interest in musculoskeletal biology, metabolism and disease. He is an NHMRC Senior Research Fellow and is a Scientific Director of the Centre for Orthopaedic and Trauma Research, University of Adelaide. As Head of the Bone Cell Biology Group, he runs an integrated research programme into the biology of osteoclasts, osteoblasts and osteocytes. He also has an ongoing interest in bone tumour biology, including osteosarcoma, giant cell tumour of bone and multiple myeloma. The group has a particular interest in the pathobiology of orthopaedic problems, such as aseptic loosening of implants, fracture repair and osteomyelitis/peri-prosthetic joint infection (PJI). He has published more than 120 papers related to bone pathophysiology. His research has attracted more than $9.5million in competitive research funding. Prof. Atkins is a committee member of the Australian New Zealand Orthopaedic Research Society (ANZORS) and is the representative to the International Combined Orthopaedic Research Societies (ICORS). He is a previous Councillor and Honorary Secretary to the Australian New Zealand Bone and Mineral Society (ANZBMS). Prof Atkins is also the Post-graduate Coordinator for the Discipline of Orthopaedics and Trauma.

  Click here to read an interview with Gerald Atkins.

• Publications

  2015

  Atkins GJ, Prideaux M and Findlay DM (2015) Osteocytes and bone regeneration in ‘A Tissue Regeneration Approach to Bone and Cartilage Repair’. H. Zreiqat, V. Rosen and C. Dunstan Eds. Springer-Verlag, Berlin, Germany, pp39-52.
  
   Ito N, Wijenayaka AR, Prideaux M, Kogawa M, Ormsby RT, Evdokiou A, Bonewald LF, Findlay DM, Atkins GJ. (2015) Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli. Molecular and Cellular Endocrinology 399:208-218. DOI: 10.1016/j.mce.2014.10.007. PMID:25458698
  
  Liapis V, Labrinidis A, Zinonos I, Hay S, Ponomarev V, Panagopoulos V, DeNichilo M, Ingman W, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A. (2015) Hypoxia-activated pro-drug TH-302 exhibits potent tumour suppressive activity and cooperates with chemotherapy against osteosarcoma. Cancer Letters 357(1):160-9. doi: 10.1016/j.canlet.2014.11.020. PMID:25444931
   
  Gulati K, Kogawa M, Makar S, Atkins GJ, Findlay DM, Losic D. (2015) Titania nanotubes as local therapeutic modification for implants. In “Electrochemically Engineered Nanoporous Materials - Methods, Properties and Applications" Eds. Losic and Santos, Springer-Verlag, pp307-355.
  
  van de Pol GJ, Iselin LD, Callary SA, Atkins GJ, Thewlis D, Solomon LB. (2015) Impaction bone grafting has potential as an adjunct to the surgical stabilisation of osteoporotic tibial plateau fractures: early results of a case series. Injury 46(6):1089-96. doi: 10.1016/j.injury.2015.02.019. PMID: 25771446
   
  Rahman S, Atkins GJ, Findlay DM, Losic D. (2015) Nanoengineered drug releasing aluminium wire implants: a model study for localized bone therapy. Journal of Materials Chemistry B 3(16):3288-3296.
   
  Saji VS, Kumeria T, Rahman S, Prideaux M, Gulati K, Atkins GJ, Losic D. (2015) Localized drug delivery of selenium (Se) using nanoporous carriers for potential cancer therapy. Journal of Materials Chemistry B 3:7090-7098.
   
  Yang D, Turner A, Wijenayaka AR, Anderson PH, Morris HA, Atkins GJ. (2015) 1,25-Dihydroxyvitamin D3 and Extracellular Calcium Promote Mineral Deposition via NPP1 activity in a Mature Osteoblast Cell Line MLO-A5. Molecular and Cellular Endocrinology Jun 6;412:140-147. doi: 10.1016/j.mce.2015.06.005. PMID: 26054750
   
   Wijenayaka AR, Yang D, Prideaux M, Ito N, Kogawa M, Anderson PH, Morris H, Solomon LB, Loots GG, Findlay, DM, Atkins GJ. (2015) 1a,25-dihydroxyvitamin D₃ stimulates human SOST gene expression and sclerostin secretion. Molecular and Cellular Endocrinology Sep 15;413:157-67. doi: 10.1016/j.mce.2015.06.021.  PMID: 26112182
   
  Clarke MV, Russell PK, Findlay DM, Anderson PH, Atkins GJ, Zajac J, Davey RA. (2015) A role for the calcitonin receptor to limit bone loss during lactation in mice by inhibiting osteocytic osteolysis. Endocrinology 156(9):3203-14. doi: 10.1210/en.2015-1345. PMID: 26135836
   
  Rahman S, Ormsby R, Santos A, Atkins GJ, Findlay DM, Losic D (2015) Nanoengineered drug-releasing aluminium wire implants: Comparative investigation of nanopore geometry, drug release and osteoblast cell adhesion. RSC Advances 5:75004-75014. DOI: 10.1039/C5RA10418A.
  
  

  2016

  
  Saad S, Dharmapatni AASSK, Crotti TN, Cantley MD, Algate K, Findlay DM, Atkins GJ, Haynes DR. (2016) Semaphorin-3a, neuropilin-1 and plexin-a1 in prosthetic-particle induced bone loss. Acta Biomaterialia Jan 15;30:311-8. doi: 10.1016/j.actbio.2015.11.025. PMID: 26602825.
   
  Triliana R, Nga N, Sawyer RK, Atkins GJ, Morris HA, Anderson PH. (2016) Skeletal characterization of a mature osteoblast-vdr transgenic (obvdr- b6)mouse model. Journal of Steroid Biochemistry and Molecular Biology doi: 10.1016/j.jsbmb.2015.08.009. PMID: 26343450 (In Press)
   
  Rahman S, Gulati K, Kogawa M, Atkins GJ, Pivonka P, Findlay DM, Losic D. (2016) Drug Diffusion, Integration and Stability of Nano-Engineered Drug-Releasing Implants in Bone Ex-Vivo. Journal of Biomedical Materials Research A 104A:714–725. doi: 10.1002/jbm.a.35595. PMID: 26481558
   
  Reinke DC, Kogawa M, Barratt KR, Morris HA, Anderson PH, Atkins GJ. (2016) Evidence for Altered Osteoclastogenesis in Splenocyte Cultures from Cyp27b1 Knockout Mice. Journal of Steroid Biochemistry and Molecular Biology doi: 10.1016/j.jsbmb.2015.11.015 PMID: 26639637.
   
  DeNichilo MO, Shoubridge AJ, Panagopoulos V, Liapis V, Zininos I, Hay S, Panagopoulos RA, Rayner, Atkins GJ, Findlay DM, Evdokiou A. (2016) Peroxidase enzymes regulate collagen biosynthesis and matrix mineralization by human osteoblasts. Calcified Tissue International 98(3):294-305. PMID: 26643175.
   
  Liapis V, Labrinidis A, Zinonos I, Hay S, Ponomarev V, Panagopoulos V, DeNichilo M, Ingman W, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A. (2016) Anticancer efficacy of the hypoxia-activated pro-drug TH-302 in osteolytic breast cancer murine models. Cancer Medicine 5(3):534-45 doi: 10.1002/cam4.599. PMID: 26749324.
   
  Ryan J, Sawyer RK, Atkins GJ, Anderson PH, Morris HA. (2016) Sex-related differences in the skeletal phenotype of aged vitamin D receptor global knockout mice. Vitamin D Workshop Special Edition. Journal of Steroid Biochemistry and Molecular Biology doi: 10.1016/j.jsbmb.2015.12.005 PMID: 26690785.
  
  Wijenayaka AR, Prideaux M, Yang D, Morris H, Findlay, DM, Anderson PH, Atkins GJ. (2016) Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D3. Journal of Steroid Biochemistry and Molecular Biology doi: 10.1016/j.jsbmb.2015.12.006. PMID: 26690786.
   
  Ormsby RT, Cantley M, Kogawa M, Solomon LB, Haynes DR, Findlay DM, Atkins GJ. (2016) Evidence that osteocyte perilacunar remodelling contributes to polyethylene wear particle induced osteolysis. Acta Biomaterialia 33:242-51. doi:10.1016/j.actbio.2016.01.016 PMID: 26796208.
  
  Prideaux M, Findlay DM, Atkins GJ. (2016) Osteocytes: the master cells in bone remodelling. Current Opinion in Pharmacology 28: 24-30. doi: 10.1016/j.coph.2016.02.003 PMID: 26927500.
   
  Yang D, Turner A, Anderson PH, Morris HA, Atkins GJ. (2016) Comparison of the biological effects of exogenous and endogenous 1,25-dihydroxyvitamin D on the mature osteoblast cell line MLO-A5. Vitamin D Workshop Special Edition. Journal of Steroid Biochemistry and Molecular Biology doi: 10.1016/j.jsbmb.2016.03.004. PMID: 26949105.
   
  Gulati K, Kogawa M, Prideaux M, Lima-Marques L, Findlay DM, Atkins GJ*, Losic D*. (2016) Anodized 3D Printed Titanium Implants with Dual Micro- and Nano-Scale Topography Promotes Interaction with Human Osteoblasts and Osteocyte-Like Cells. Journal of Tissue Engineering and Regenerative Medicine (In Press)
   
  Prideaux M, Schutz CR, Wijenayaka AR, Findlay DM, Campbell DG, Solomon LB, Atkins GJ. (2016) Isolation of osteocytes from human trabecular bone. Bone 88:64-72. doi: 10.1016/j.bone.2016.04.017. PMID: 27109824.

  Gulati K, Kogawa M^†, Prideaux M^†, Findlay DM, Atkins GJ*, Losic D*. (2016) Nano-Engineered Titanium Implants: Therapeutic Efficacy in 3D Cell Culture Model. Materials Science and Engineering C: Materials for Biological Applications (In Press)

• Files

  • Interview - Gerald_Atkins_Interview.pdf [337.8K] (application/pdf)

Entry last updated: Tuesday, 29 Mar 2022

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