Dr Ian Musgrave

• Biography/ Background

  Dr Musgrave is a molecular pharmacologist/toxicologist who works at the University of Adelaide, Australia. He has a broad interest in the understanding of how surface receptors can modulate neuronal function and survival, as well as interests in natural product pharmacology and drug design. As well he is interested in evolutionary biology, science communication (committee member of SA Science Communicators) and an avid amateur astronomer.

  He did postdoctoral work in the Institute of Pharmacology at the Free University of Berlin in 1991-1994, returning to Australia in 1994. He has collaborated with Professor John Carver, Dr. Scot Smid and Professor Colin Barrow on using natural products to attack the neurodegeneration process in Alzheimer’s Disease. He was recently elected as convenor of the Toxicology Special Interest Group of the Australasian Society for Pharmacology and Toxicology. He is collaborating with Professor Roger Byard on the forensic implications of herbal medicines. He has held ARC funding and currently holds NH&MRC funding.

   

• Research Interests

  Neuroprotection, neurotoxicology, natural product pharmacology, natural products as drugs, anti-amyoid drugs, anti-amyloid drugs and HIV, herbal medicine safety. See more on my research homepage.

• Publications

  For a full list and download links, see my publications profile on Google Scholar: Ian Musgrave

  Selected Publications:

  1: Musgrave IF, Farrington RL, Hoban C, Byard RW. Caffeine toxicity in forensic
  practice: possible effects and under-appreciated sources. Forensic Sci Med
  Pathol. 2016 Jun 25. [Epub ahead of print] Review. PubMed PMID: 27344159.
  2: Maiden NR, Musgrave I, Fisk W, Byard RW. Pig Organ Energy Loss Comparison
  Experiments Using BBs. J Forensic Sci. 2016 May;61(3):679-86. doi:
  10.1111/1556-4029.13056. Epub 2016 Feb 25. PubMed PMID: 27122406.
  3: Jayne T, Newman M, Verdile G, Sutherland G, Münch G, Musgrave I, Moussavi Nik 
  SH, Lardelli M. Evidence For and Against a Pathogenic Role of Reduced γ-Secretase
  Activity in Familial Alzheimer's Disease. J Alzheimers Dis. 2016 Apr
  4;52(3):781-99. doi: 10.3233/JAD-151186. PubMed PMID: 27060961.
  4: Das S, Stark L, Musgrave IF, Pukala T, Smid SD. Bioactive polyphenol
  interactions with β amyloid: a comparison of binding modelling, effects on fibril
  and aggregate formation and neuroprotective capacity. Food Funct. 2016
  Feb;7(2):1138-46. doi: 10.1039/c5fo01281c. PubMed PMID: 26815043.
  5: Calabrese AN, Liu Y, Wang T, Musgrave IF, Pukala TL, Tabor RF, Martin LL,
  Carver JA, Bowie JH. The Amyloid Fibril-Forming Properties of the Amphibian
  Antimicrobial Peptide Uperin 3.5. Chembiochem. 2016 Feb 2;17(3):239-46. doi:
  10.1002/cbic.201500518. Epub 2015 Dec 16. PubMed PMID: 26676975.
  6: Coghlan ML, Maker G, Crighton E, Haile J, Murray DC, White NE, Byard RW,
  Bellgard MI, Mullaney I, Trengove R, Allcock RJ, Nash C, Hoban C, Jarrett K,
  Edwards R, Musgrave IF, Bunce M. Combined DNA, toxicological and heavy metal
  analyses provides an auditing toolkit to improve pharmacovigilance of traditional
  Chinese medicine (TCM). Sci Rep. 2015 Dec 10;5:17475. doi: 10.1038/srep17475.
  PubMed PMID: 26658160; PubMed Central PMCID: PMC4675079.
  7: Hoban CL, Byard RW, Musgrave IF. A comparison of patterns of spontaneous
  adverse drug reaction reporting with St. John's Wort and fluoxetine during the
  period 2000-2013. Clin Exp Pharmacol Physiol. 2015 Jul;42(7):747-51. doi:
  10.1111/1440-1681.12424. PubMed PMID: 25988866.
  8: Moussavi Nik SH, Newman M, Wilson L, Ebrahimie E, Wells S, Musgrave I, Verdile
  G, Martins RN, Lardelli M. Alzheimer's disease-related peptide PS2V plays
  ancient, conserved roles in suppression of the unfolded protein response under
  hypoxia and stimulation of γ-secretase activity. Hum Mol Genet. 2015 Jul
  1;24(13):3662-78. doi: 10.1093/hmg/ddv110. Epub 2015 Mar 26. PubMed PMID:
  25814654.
  9: Liu Y, Carver JA, Ho LH, Elias AK, Musgrave IF, Pukala TL. Hemin as a generic 
  and potent protein misfolding inhibitor. Biochem Biophys Res Commun. 2014 Nov
  14;454(2):295-300. doi: 10.1016/j.bbrc.2014.10.062. Epub 2014 Oct 18. PubMed
  PMID: 25450392.
  10: Elias AK, Scanlon D, Musgrave IF, Carver JA. SEVI, the semen enhancer of HIV 
  infection along with fragments from its central region, form amyloid fibrils that
  are toxic to neuronal cells. Biochim Biophys Acta. 2014 Sep;1844(9):1591-8. doi: 
  10.1016/j.bbapap.2014.06.006. Epub 2014 Jun 17. PubMed PMID: 24948476.
  11: Gilbert JD, Musgrave IF, Hoban C, Byard RW. Lethal hepatocellular necrosis
  associated with herbal polypharmacy in a patient with chronic hepatitis B
  infection. Forensic Sci Int. 2014 Aug;241:138-40. doi:
  10.1016/j.forsciint.2014.05.021. Epub 2014 Jun 2. PubMed PMID: 24915453.
  12: Blacksell L, Byard RW, Musgrave IF. Forensic problems with the composition
  and content of herbal medicines. J Forensic Leg Med. 2014 Mar;23:19-21. doi:
  10.1016/j.jflm.2014.01.008. Epub 2014 Jan 25. PubMed PMID: 24661699.
  13: Byard RW, Musgrave I, Hoban C, Bunce M. DNA sequencing and metabolomics: new 
  approaches to the forensic assessment of herbal therapeutic agents. Forensic Sci 
  Med Pathol. 2015 Mar;11(1):1-2. doi: 10.1007/s12024-014-9537-8. Epub 2014 Feb 11.
  PubMed PMID: 24515579.
  14: Wong DY, Musgrave IF, Harvey BS, Smid SD. Açaí (Euterpe oleraceae Mart.)
  berry extract exerts neuroprotective effects against β-amyloid exposure in vitro.
  Neurosci Lett. 2013 Nov 27;556:221-6. doi: 10.1016/j.neulet.2013.10.027. Epub
  2013 Oct 22. PubMed PMID: 24161892.
  15: Liu Y, Pukala TL, Musgrave IF, Williams DM, Dehle FC, Carver JA. Gallic acid 
  is the major component of grape seed extract that inhibits amyloid fibril
  formation. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6336-40. doi:
  10.1016/j.bmcl.2013.09.071. Epub 2013 Oct 1. PubMed PMID: 24157371.
  16: Calabrese AN, Markulic K, Musgrave IF, Guo H, Zhang L, Bowie JH. Structural
  and activity changes in three bioactive anuran peptides when Asp is replaced by
  isoAsp. Peptides. 2012 Dec;38(2):427-36. doi: 10.1016/j.peptides.2012.10.001.
  Epub 2012 Oct 13. PubMed PMID: 23069634.
  17: Smid SD, Maag JL, Musgrave IF. Dietary polyphenol-derived protection against 
  neurotoxic β-amyloid protein: from molecular to clinical. Food Funct. 2012
  Dec;3(12):1242-50. doi: 10.1039/c2fo30075c. Review. PubMed PMID: 22929970.
  18: Koudelka T, Dehle FC, Musgrave IF, Hoffmann P, Carver JA. Methionine
  oxidation enhances κ-casein amyloid fibril formation. J Agric Food Chem. 2012 Apr
  25;60(16):4144-55. doi: 10.1021/jf205168t. Epub 2012 Apr 11. PubMed PMID:
  22443319.
  19: Weekley CM, Aitken JB, Musgrave IF, Harris HH. Methylselenocysteine treatment
  leads to diselenide formation in human cancer cells: evidence from X-ray
  absorption spectroscopy studies. Biochemistry. 2012 Jan 24;51(3):736-8. doi:
  10.1021/bi201462u. Epub 2012 Jan 17. PubMed PMID: 22242710.
  20: Harvey BS, Ohlsson KS, Mååg JL, Musgrave IF, Smid SD. Contrasting protective 
  effects of cannabinoids against oxidative stress and amyloid-β evoked
  neurotoxicity in vitro. Neurotoxicology. 2012 Jan;33(1):138-46. doi:
  10.1016/j.neuro.2011.12.015. Epub 2012 Jan 3. PubMed PMID: 22233683.
  21: Moussavi Nik SH, Wilson L, Newman M, Croft K, Mori TA, Musgrave I, Lardelli
  M. The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low
  oxygen/oxidative stress. J Alzheimers Dis. 2012;28(3):515-30. doi:
  10.3233/JAD-2011-110533. PubMed PMID: 22045484.
  
  
  

  22: Wilkins JS, Stanyon C, Musgrave I. Selection without replicators: the origin of genes,
  and the replicator/interactor distinction in etiobiology Biol Philos 2012 27:215–239
  23: Vega IF, Rittschof D, Dickinson GH, Musgrave I. Evolutionary Proteomics: 
  Empowering Tandem Mass Spectrometry and Bioinformatics Tools for the Study of Evolution. 
  In: Tandem Mass Spectrometry – Applications and Principles. 2012 Pp. 57-86.

   

  Publications via Google Scholar

  http://scholar.google.com/citations?user=eU_PyAEAAAAJ

• Community Engagement

  A comittee member of the Australian Science Communicators (South Australia), Dr. Musgrave has given several community talks and radio interviews on various aspects of science. He has been interviewed for the TV program Today Tonight three times.  

  Dr. Musgrave writes a regular column for The Conversation on issues relating to Pharmacology and Toxicology. His Conversation article ‘Doctors' orders: debunking homeopathy once and for all’, is included in The Best Australian Science Writing 2012 anthology

• Media Expertise

  Categories	Medicine & Medical Research, Science & Technology
  Expertise	Alzheimer's disease, neurodegeneration, neuropharmacology, amyloid, antioxidants, natural products as drugs, toxicology, toxicology of natural products, herbal medicine toxicology, molecular toxicology, molecular pharmacology, receptor structure and function, Pharmacology Teaching
  Notes	Member, Australasian Society of Clinical and Experimental Pharmacology and Toxicology (Chair, Toxicology Special Interest Group, Member, Teaching and Drugs Discovery special interest groups). Member, Australian Neuroscience Society Member, Australian Science Communicators. Co-convenor, Adelaide Healthy Ageing Research Cluster (HARC) (2007-2010) AWARD: 1995 ASCEPT Young Investigator

Entry last updated: Friday, 18 Mar 2022

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