Herbal medicine's hidden risks pose threat to health

Monday, 6 February 2017

The misperception that herbal medicines are 'safe' because they are derived from natural materials and have been in use for thousands of years could see people unknowingly putting their health at risk, say University of Adelaide researchers.

In a paper published today in the Medical Journal of Australia, researchers have highlighted a range of issues relating to the preparation of complementary medicines (including herbal products) and their use. The researchers found that some traditional herbal preparations contain toxic chemicals from both animals and plants, as well as heavy metals and pesticides.

"Toxic side effects of herbal medicines used in traditional societies have typically not been reported, and this is often cited in favour of their safety. However, the lack of systematic observation has meant that even serious adverse reactions, such as the kidney failure and liver damage caused by some plant species, have gone unrecognised until recently," says lead author Professor Roger Byard, Professor of Pathology at the University of Adelaide.

The review – by researchers from the University of Adelaide, Murdoch University and Curtin University – has important implications for consumers, as more than half of those using complementary medicines (including herbal products) do not inform their doctors of use. Patients often use these products alongside conventional medications and with other herbal medications.

"Most of the time patients don’t recognise herbal products as a medicine, so it doesn’t come to mind when asked what medicines they are taking," says co-author Dr Ian Musgrave from the University's Discipline of Pharmacology.

"It can also be a situation of 'don’t ask, don’t tell' – medical doctors may not think to ask patients what herbal medicines they might be taking, so people don't think to mention it. The problem with this is that drug interactions are poorly recognised in herbs – not only can herbal medicines interact with traditional pharmaceutical medicines but also with other herbal medicines the patient may be using."

The authors say that due to relatively light regulation of the industry, the content and quality of herbal preparations are not as tightly controlled as standard pharmaceuticals.

"A significant number of traditional herbal medicines do not comply with Australian regulations. In some cases ingredients are either not listed or their concentrations are recorded inaccurately on websites or labels. In other cases a botanical species may be replaced with another if it is difficult to source or too expensive. The replacement species may be potentially toxic. Most worryingly, a few products are illegally adulterated with standard pharmaceuticals to increase the effectiveness of the herbal product," Dr Musgrave says.

Professor Byard says: "We feel it would be appropriate for the Therapeutic Goods Administration to require manufacturers to have samples independently tested before placing them on the market. Legal action should be considered in cases of non-compliance with applicable regulations, and preparations containing illegal substances should be banned."

Dr Musgrave says: "Any sensible way to overcome these issues will involve more effort: more testing, more documentation, and this will naturally incur more costs for industry. There will be a reluctance from industry to do this, but while they claim that for thousands of years they have been using herbal products without such tests, the potential risks to human health mean that there is due cause for reasonable, scientifically rigorous testing."

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