Dr Qi Zhang to speak at School of Biomedicine Seminar Series

Join SAiGENCI's EMBLAus Group Leader, Dr Qi Zhang, as she presents at the School of Biomedicine Seminar Series:

"Molecular basis for mammalian gene repression"

Maintenance of cell identity relies on the repression of lineage-specific genes, which is largely regulated by the histone modifier polycomb repressive complex 2 (PRC2).  Dysregulation of PRC2 contributes to human diseases, including cancer.  PRC2 maintains gene repression by depositing repressive histone marks (H3K27me3) and its enzymatic activity and recruitment to chromatin are regulated by cofactors such as DNA, RNA and accessory subunits.  In this seminar, Dr Zhang will demonstrate how RNA regulates PRC2 mechanistically, through a combination of approaches including biochemistry, structural biology, cell biology and genomics

Zoom:  811 7385 1770  Passcode:  548743