Naganishia albida

Synonymy:
Cryptococcus albidus, Cryptococcus diffluens

Naganishia albida  infections in humans are rare. 

A phylogenetic review by Liu et al. (2015) reclassified Cryptococcus albidus as Naganishia albida. N. albida has variable growth at 37oC and infections in humans are rare. Impaired cellular immunity is the most common risk factor with HIV infection and low CD4 counts a common comorbidity (Morales-Lopez and Garcia-Effron, 2021).

RG-1 organism.

Culture: 
Colonies (SDA) are cream-coloured smooth, mucoid, glabrous, yeast-like.

Microscopy: 
Globose to ovoid budding yeast-like cells, 3.5-8.8 x 5.5-10.2 μm. Pseudohyphae are absent.

India ink preparation: 
Positive - distinct thin capsules are present.

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube - L-Sorbose v L-Arabinose + D-Glucitol +
Fermentation   Sucrose + D-Arabinose v 𝝰-M-D-Glucoside v
Glucose - Maltose + D-Ribose v D-Gluconate +
Galactose - Cellobiose + L-Rhamnose v DL-Lactate v
Sucrose - Trehalose +,w D-Glucosamime - myo-Inositol +
Maltose - Lactose v N-A-D-glucosamine - 2-K-D-Gluconate +
Lactose - Melibiose v Glycerol v D-Glucuronate +
Trehalose - Raffinose + Erythritol v Nitrate +
Assimilation   Melezitose + Ribitol v Urease +
Glucose + Soluble Starch v Galactitol v 0.1% Cycloheximide -
Galactose v D-Xylose + D-Mannitol + Growth at 37C v

Key features: 
Naganishia albida has variable growth at 37C. 

Antifungal susceptibility: Naganishia albida (Australian national data); MIC µg/mL. 
Antifungal No ≤0.03 0.06 0.125 0.25 0.5 1 2 4 8 16 32 ≥64
AMB 4           3 1          
FLU 4                     3 1
ISAV 2       1   1            
VORI 4       1   2     1      
POSA 4         1 2     1      
ITRA 4       2 1         1    
5FC 4                       4

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