Candida metapsilosis

Candida metapsilosis is recognised as part of the Candida parapsilosis species complex (Tavanti et al., 2005).

It is phenotypically indistinguishable from C. parapsilosis, C. orthopsilosis and Lodderomyces elongisporusand is best identified by ITS sequencing or MALDI-ToF MS.

RG-2 organism.

Culture:
Colonies (SDA) white to cream-coloured smooth, glabrous, yeast-like.

Microscopy:
Ellipsoid, subglobose to fusiform budding blastoconidia, 4 x 3-6 µm, with some larger subglobose forms present.

India ink preparation:
Negative - no capsules present.

Dalmau plate culture:
Abundant, much branched pseudohyphae produced.

Physiological Tests: + Positive, - Negative, v Variable, w Weak, s Slow, nd No Data
Germ Tube	-	L-Sorbose	+	L-Arabinose	+	D-Glucitol	+
Fermentation		Sucrose	+	D-Arabinose	-	𝝰-M-D-Glucoside	+
Glucose	+	Maltose	+	D-Ribose	+	D-Gluconate	+
Galactose	+	Cellobiose	-	L-Rhamnose	-	DL-Lactate	-
Sucrose	+	Trehalose	+	D-Glucosamime	-	myo-Inositol	-
Maltose	-	Lactose	-	N-A-D-glucosamine	+	2-K-D-Gluconate	+
Lactose	-	Melibiose	-	Glycerol	+	D-Glucuronate	-
Trehalose	-	Raffinose	-	Erythritol	-	Nitrate	-
Assimilation		Melezitose	+	Ribitol	+	Urease	-
Glucose	+	Soluble Starch	v	Galactitol	-	0.1% Cycloheximide	-
Galactose	+	D-Xylose	+	D-Mannitol	+	Growth at 37C	+

Key features:
Candida metapsilosis cannot be distinguished morphologically from C. parapsilosis and C. orthopsilosis, but can be identified by ITS sequencing (Asadzadeh et al. 2009, Borman et al. 2009, Tavanti et al. 2005) and MALDI-TOF MS analysis.

Antifungal susceptibility: *Candida metapsilosis* (Australian national data); MIC µg/mL.
Antifungal	No	≤0.016	0.03	0.06	0.125	0.25	0.5	1	2	4	≥64
AMB	72			14	7	13	19	15	2	1	1
FLU	72					1	6	33	27	4	1
ISAV	13	9	1	3
VORI	72	21	34	12	5
POSA	72	12	15	25	18	1		1
ITRA	42	5	6	9	11	10	1
ANID	53			2	21	14	13	2	1
MICA	53				9	21	22	1
5FC	41			29	7	4	1

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