Dr Dee Domingo
Research Associate
Organisation unit
College of Health
Centre for Cancer Biology
Location
Adelaide University, Bradley Building, Level 10
Room: HB10-25,
Desk: WS32
Contact
About me
Dr Dee Domingo is a Postdoctoral Researcher
in the Neurovascular Research Laboratory (Neural Crest and Cardiac Development Group)
at the Centre for Cancer Biology. Her research investigates the cellular and
molecular mechanisms by which Neural Crest Cells influence the developing heart,
with a particular interest in how disruption to these processes drives
Congenital Heart Defects including Pulmonary Stenosis.
Neural Crest cells play a
critical role in guiding the remodelling of the pharyngeal arch arteries – a series
of embryonic blood vessels that give rise to the great vessels of the heart,
including the aorta and pulmonary artery. Dr Domingo’s work centres on how Neural
Crest Cell-Specific Notch signalling uniquely drives the remodelling of the 6th
pharyngeal arch artery (remodels into the pulmonary artery) and the
pulmonary valves.
Using conditional knockout mouse
models, she examines how loss of Notch signalling in Neural Crest Cells produces
clinically relevant stenotic phenotypes, smooth muscle loss and dysregulated
cell signalling and differentiation. Dr Domingo’s Research is underpinned by a
suite of advanced imaging and molecular techniques, including whole embryo
light sheet fluorescence microscopy, 3D vascular modelling, fetal
echocardiography, immunofluorescence and immunohistochemistry.
Last updated
on 03/06/2026
by Dee Domingo