Reproductive Success Group

Reproductive success

Shedding new light on reproductive success and IVF

The Reproductive Success Group, led by ARC Future Fellow Associate Professor Kylie Dunning, focuses on improving fertility outcomes through interdisciplinary research at the interface of biology, engineering and the physical sciences.

Our work centres on understanding and enhancing oocyte (egg) quality and early embryo development-key determinants of reproductive success in both clinical and agricultural settings. We use advanced, non-invasive imaging and diagnostic technologies, including light-based approaches, to generate objective measures of developmental potential.

A major focus of the group is translating these discoveries into practical tools for assisted reproduction. We work closely with clinicians, embryologists and industry partners to develop technologies that improve how eggs and embryos are assessed and selected in IVF.

Translation is further supported through IVF VET Solutions, an internal university initiative led by the group, which delivers specialised reproductive services including the Mouse Embryo Assay (MEA) - a quality control bioassay used by IVF laboratories to detect toxicity in culture media, oils and consumables.

Beyond human health, we apply our expertise to agriculture through industry partnerships.

We are based within Robinson Research Institute and the Institute for Photonics and Advanced Sensing, and collaborate closely with the Centre of Light for Life, leveraging world-class imaging platforms to drive innovation in reproductive science. Our team fosters a collaborative and supportive research environment, with a strong commitment to training and mentoring the next generation of scientists.

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Embryology and in vitro models (oocyte maturation, in vitro fertilisation, follicle culture and embryo culture)

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Metabolic imaging of live oocytes and embryos

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Non-invasive assessments of oocyte and embryo health

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Embryo transfer and assessment of fetal and placental outcomes

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Advanced light-based imaging (light-sheet microscopy and hyperspectral microscopy; digital holographic microscopy)

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IVF VET Solutions (Mouse embryo assay (MEA) for IVF quality control)

Explore the Reproductive Success Group

Our interdisciplinary team integrates expertise in reproductive biology, biomedical engineering and the physical sciences to address one of the most pressing challenges in modern healthcare: improving reproductive outcomes. We use advanced, non-invasive imaging and diagnostic technologies to uncover the biology that underpins oocyte quality and early embryo development.

Our research is focused on translation. We work closely with clinicians, embryologists and industry partners to develop objective tools that improve the assessment and selection of eggs and embryos in IVF. These approaches aim to increase success rates, reduce the need for multiple treatment cycles, and improve the experience for patients.

Beyond clinical IVF, our work extends to agriculture and conservation, where improving reproductive efficiency has significant impacts on productivity and genetic sustainability.

Associate Professor Kylie Dunning

Research Lead

Dr Cheow Yuen Tan (Tiffany)

Postdoctoral researcher

Dr Darren Jin Xiang Chow

Postdoctoral researcher

Dr Megan Lim

Postdoctoral researcher

Dr Tan Dai Nguyen

Postdoctoral researcher

Dr Avinash Upadhya

Postdoctoral researcher

Shan Li

PhD student

Tong Li

PhD student

Zoe Delaney

PhD student

Masha Gvozdeva

Honours student


A major limitation in IVF is the inability to reliably identify the healthiest oocyte and embryo for transfer. Our research focuses on developing non-invasive diagnostic approaches to address this challenge. We use advanced microscopy and downstream analyses to study preimplantation embryo development, comparing healthy embryos with those that fail to develop or result in implantation failure or pregnancy loss. This work aims to transform how fertility specialists select the highest-quality eggs and embryos, improving success rates and reducing the burden of treatment.

We apply cutting-edge optical imaging approaches, including light-sheet, hyperspectral and digital holographic microscopy, to investigate the biological mechanisms underlying oocyte and embryo quality. These techniques provide high-resolution molecular and structural information while preserving embryo viability.

A key focus of our work is non-invasive metabolic profiling. By analysing endogenous signals, we gain insight into embryo health and developmental potential, identifying objective biomarkers of quality.

Clinical translation underpins all our research. We rigorously assess the safety of our imaging approaches using validated preclinical models, determining potential effects on embryo development, implantation, live birth and offspring health. This ensures our technologies are not only informative, but also safe, practical and ready for future use in fertility clinics.

Contact the Reproductive Success Group

Location

Location
Reproductive Success Group
Robinson Research Institute, Adelaide University
Level 2, Helen Mayo South Building, East Campus, Adelaide, SA 5005

Telephone

Phone: +61 8 8313 1013

Email

Email: kylie.dunning@adelaide.edu.au

Contact us

Robinson Research Institute

Location

Location
Robinson Research Institute
Adelaide University
Ground Floor, Norwich House
55 King William Road
North Adelaide, SA 5006

Email

Email: robinsonresearch@adelaide.edu.au